We've been using a U3818DW to replace a pair of 1600x1200 displays on an well-spec'd but antique Dell Precision + Quadro K2200-based development workstation. Based on six weeks experience, we expect to buy more in future.
Though multiple screens on a PC might be cheaper, we concluded they're bad news for productivity, collaboration and perhaps ergonomics. By comparison Dell's display manager allows you to arrange the U3818DW screen in twenty different ways. Full screen works well for Adobe Creative Cloud. In general we found that in thirds are the best sizes, each being roughly 366x291mm, which is about 20% larger than portrait A4 with space for browser tabs and the Windows taskbar. A ⅓:⅔ layout works well for software development and testing (IDE 1280x1600, application 2560x1600), and ⅓:⅓:⅓ is excellent for academic writing (web searching, reference management and editing all 1280 x 1600). We've not found a use for ½:½ yet, even though that was forced on us by our earlier two-screen layout. An unexpected benefit was the ease of demonstration to a colleague, where 21:9 3840x1600 seems to work better than 16:9 3840×2160.
The U3818DW also offers a picture-in-picture KVM, which probably depends on how the other system's display drivers work. In our tests the keyboard and mouse behaved flawlessly but we couldn't convince a second (Dell laptop) system to to fit its screen into the constrained display area.
I bought this after my thunderbolt died. I run it on a MB pro 2018 and it works well. The usb-c single cable deal is a bit unstable though. Initially it was what I was trying to work to but it seems it did other funny things to the Mack book and in the end I just went for a usb-c to hdmi cable and use a charger too
Replaced my Thunderbolt (TBD) display and 24" monitor dual setup.
I've set this up using a CalDigit USB-C hub with DisplayPort from the hub to the monitor. The only thing you won't get working (ever, as it's not supported) is controlling the brightness from the keyboard but it's pretty simple to use the standard toggles on the monitor to control this. With the hub I only have a single USB-C to the MBP... got a MBP? get a hub.
I've bypassed the built in speakers and use my standalone speakers so cannot comment on the sound.
The monitor is a decent size and is definitely not over large, probably wouldn't want to go larger though. On a mac use it with BetterSnapTool or Magnet to get the most out of it along with Unclutter to control your window layouts on demand.
For those of you coming from a Thunderbolt display... this monitor is really non reflective, my TBD was like a mirror and I would get headaches from the unwanted reflections, no problem anymore. Colour is pretty damn accurate once you fiddle a little.
Two months in and I love it. I seldom do reviews and I'm only doing this one as I researched a lot prior to purchasing and there were still questions in my mind, hope this helps someone. It's a zero regret purchase.
Pic shows three web pages side by side and this monitor is great for development work.