For anyone who walks long distances and is prone to blisters these are a must. Used many times over the years,they provide instant relief. The key when applied is to leave it in place until it starts to come off by itself. The healing process takes place by reacting with the blister plaster. Purchasing a new pair of shoes within an hour my wife discovered a large painful blister on the ball of her right foot. She tried one of these and could not believe the result. She now swears by them and recommends them to everyone.