This is a book I would sincerely recommend. As a debut novel it is probably fair to acknowledge that the prose style could, on occaison, be improved upon. However, this does not detract from the enjoyment of the book because this is a story that is predominantly about a Big Idea. The transhumanist philosophy, and the possible effects its adoption would have to our way of life, is the real character here.
The Transhumanist Wager encourages us to look up from the "here and now" and speculate on what it will mean to be human in the future. It does not dictate this future vision, but it does effectively set the basis from which we can form our own individual feelings. It shows a few of the challenges and pitfalls that might arise - both practical and ethical - and provokes the reader to consider their own ideas.
The characters are somewhat thin, with the exception of the main protagonist. However, this is OK since everyone is (to an extent) subordinate to the Big Idea. I would expect that, having introduced the scenario of Transhumanism, the author will be able to bring more layered characterisation to any sequel.
The main character is more interesting and some might say it would be improbable that so much drive and intellect could be collected in one person. Maybe. However, this is a story about a dramatic (to say the least) revolution and such a coup could only be carried off by someone of superhuman abilities.
It is a compelling story, and predicts a step change in human evolution that many futurists say is closer than we imagine. Give it a try and you will find yourself developing opinions on issues you may never have considered before......