Bought this game after watching it played on Wil Wheaton's Tabletop and have been very pleased to add this to my stack, prior to this game I had not owned a truly co-operative game and to be honest I am not sure I will find another to beat it.
First off the quality of the board and pieces is top notch, the look and feel is lovely and having played it a fair few times now no sign of wear and tear has appeared on any of the pieces or cards.
The game mechanics are simple to understand and each player has access to a card that gives a quick run down of the basic turns rules/actions on a general level as well as any character specific rules on their cards. This neatly means once you've played it a couple of times you don't need to refer back to the manual. Which is nice.
The game has one way to win, which is curing every disease, but many ways to lose which means even when you're a seasoned player and think you've worked out a solid strategy how to win you can be blindsided and lose. The difficulty level of the game can be altered as well using the number of Epidemic cards which is a nice touch so that you can gradually increase the challenge. Also the different player roles make each game different as skills you may have relied on previous games are now unavailable - the random selection process ensures people are forced out of their comfort zone which adds to the variety of the games.
All in all this is a brilliant game to bring people together, especially in a regular group of gamers who spend their time working out ways to screw each other in a desperate attempt to win, you won't be disappointed to spend an hour playing this.