Just one critisism, then on with the praise! The start to the book could have been better. The first chapter puts you in some mountains with a rather confusing situation between a monk and some kind of strange human (Frankenstein's monster). It confuses slightly, but from that point on, this book is a real page-turner.
An outstanding set of complex characters and a grand setting is painted for a plot which smoothly picks up Mary Shelly's characters, fast-forward's them 200 years and places them in New Orleans for a real showdown. The tension and suspense in the book has been built really well and the pace of the action keeps you hooked.
Cant wait to read the next one! (Which is surely the sign of a good first book to a trilogy?)