A big claim I know, but here goes. The Origin provided a explanation for the existence of life on Earth while Time Reborn provides and explanation for the existence of our universe and its physical properties. Both complex life and the existence of a universe with a wide range of elements are highly improbable, and can only be explained by successive developments over eons of time. Darwin did not know about DNA when he wrote the Origin and there is still much to be discovered in physics, but this book provides the first account of physics which makes sense to me as a layman. No other popular account of physics and cosmology has done this.
I had to read it twice to understand the gist of it, but it was well worth the effort. I highly recommend it to anyone who wants to understand nature.