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on 20 June 2008
Ending Aging may one day be regarded as having made history. And it is fun, provoking, and informative.

Its starting point itself is eye-opening: aging isn't built into our bodies, it only results from a gradual breakdown that evolution hasn't found efficient to equip us against, picking reproduction as the preferred path for gene survival. De Grey adds that this breakdown can be fixed. Science will soon be able to engineer eternal youth, he asserts - yes, not just slow aging down but actually set back the clock. This would apparently require fixing decay in seven broad areas, for which he details the solutions. To me, a complete layman, four of the proposed solutions seem in the process of advanced medical research, two look farther off, and one, dealing with cancer, sounds somewhat unpalatable if perhaps credible (requiring regular cell transplants to a multiplicity of organs).

De Grey is not originally a biologist, but a computer programmer. He says his outsider status is an advantage. Sounds suspicious? Perhaps, but he published revolutionary research on the DNA of mitochondria (the part of the cell that generates the energy on which we live) and their role in aging; this was peer-reviewed and acclaimed by the scientific establishment. He was awarded a PhD for it at Cambridge, where he works.

Ending Aging says its goals can be achieved in 25 years. Considering the impotence of big pharma and the propensity to blunders of public government (viz. the stem cell controversy, which is detailed in the book), this sounds doubtful. But incredibly, one big hurdle to pursuing the requisite research seems to be that a number of people don't actually want to end aging. This is where De Grey turns from scientist to advocate. Apparently, the fear is that ending aging would cause grave disruption to the environment and existing social structures. So what?
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on 20 November 2009
I'm not a biologist, but I was fascinated by this book. Dr De Grey's enthusiasm is infectious, and this book makes an excellent companion piece to another bit of optimistic pop(ish) science: 'The Singularity is Near' by Ray Kurzweil.

Dr De Grey also has a most magnificent beard. Brian May, who asked "who wants to live forever?", has stupid hair. Check and mate.

If you'll excuse me, I'm off to donate money to Dr De Grey's scientific endeavours. I DO want to live forever, and I want my dad to live forever as well.
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on 16 September 2007
Ignore the somewhat pain jacket design. "Ending Aging" is definitely not some run of the mill self help book. Truth is often much stranger than fiction. De Grey is a man with a mission. Consider this improbable scenario: a hitherto unknown Cambridge scientist realises he holds the key to saving the lives of countless millions. What is he to do? In that situation what would YOU do? This is not some improbable science-fiction scenario. This is here and right now.

Molecular biology is now expanding at an explosive pace. What would happen if we were to push the rate of progress just that little bit more? Meet the real life alliance of engineers, scientists, philanthropists and volunteer fund raisers all of whom have but one thing in common. None of whom want to have an appointment with the grave or the furnace several decades from as of today.

I for one do not want to die. Read this book and warn others. The Race is ON!
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on 6 October 2007
As novel technologies are emerging at the interface of established disciplines, it becomes ever more difficult to maintain an understanding, never mind an expert knowledge, of these new areas. Such keeping up is particularly formidable in case of aging prevention- a notoriously complex and multifaceted subject that encompasses biochemistry, molecular biology, genetics, physiology, endocrinology, immunology and chemistry to name but a few areas. To briefly cover these would require a treatise the size of the British Encyclopaedia, right?

Well, fortunately, wrong!- thanks to this reader-friendly and vibrant description of the Strategies for Engineered Negligible Senescence (SENS) approach. A must to read for life sciences professionals, engineers, and all the rest of us who hopes to see humans walking on Mars, cancer and famine eradicated, the Global Warming prevented, - and way, way beyond.
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on 26 September 2014
Thanks, very interesting reading
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on 9 February 2010
The intricacies of cell biology baffle and stagger the mind.It is not surprizing then that new Organelles are still being discovered and presumably many more wil be discovered in years to come; these are Organelles we're talking about folks!--hardly superfluous structures. Before cell biologists can even approach the problem of curing old age all Organelles must be completely understood.Exactly the same applies with Enzymes:the hugely complex roles they play in all cells must be COMPLETELY UNDERSTOOD. This idea Aubrey de Grey has of " Side stepping ignorance " is akin to a man with no previous knowledge of pocket-watches taking the back off of one and fixing it with chewing gum, hoping ( in vain ) that he won't have to wind it again.

Research science-- Lab work-- they dont call them laboratories for nothing it's laborious labour. Be you an organic chemist or whatever, it's slow going.
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