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Toxicology and Risk Assessment: A Comprehensive Introduction Hardcover – 8 Feb 2008


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Review

"If you want a good toxicology text with a taste of risk assessment, it is great value." ( BTS Newsletter, Summer 2008)

"The author strikes a balance between quantitative rigor and intuitive understanding, using a lively, informal style." (Fiz Karlsruhe, December 2008)

"It is amazing that so many facets of the field are highlighted in this volume, so that every reader will find more than a single chapter from which to draw benefit. This piece is a definite must for students." (Organic Chemistry, December 2008)

"An essential book for scientists in academia, industry and government agencies who want to understand how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios." (Environmental Engineering and Management Journal, July/August 2008)

"This book provides a valuable introduction to the principles of hazard identification and risk assessment of toxicants." (Chemistry World, July 2008)

From the Back Cover

TOXICOLOGY AND RISK ASSESSMENT: A COMPREHENSIVE INTRODUCTION

HELMUT GREIM, Institut für Toxikologie und Umwelthygiene, Technische Universität München

ROBERT SNYDER, Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey

Toxicology is concerned with the health risks of human exposure to chemicals. It describes the adverse effects of chemicals in a qualitative sense, and with evaluating them quantitatively by determining how much of a chemical is required to produce a given response.

Toxicology and Risk Assessment: A Comprehensive Introduction describes the basic concepts of toxicology, and aims to equip the reader with the skills required to evaluate risks at given exposures. Topics covered include:

  • Principles in Toxicology: toxicokinetics including absorption, distribution, metabolism and excretion; the mechanisms that lead to cytotoxicity, carcinogenicity and effects on reproduction; and the toxic effects of mixtures of chemicals
  • Organ Toxicology: information on anatomy and physiology of the major organs; why they are specific targets; and the mechanisms of specific chemicals affecting these organs
  • Methods in Toxicology: the commonly used methods used for toxicity testing, both in vivo and in vitro
  • Risk Assessment: the concepts comprising hazard identification, dose–response, and exposure assessment and the different approaches for thresholded and non–thresholded effects. Recent molecular–biological results on cellular responses to genotoxic agents such as DNA–repair, halt of proliferation, and apoptosis that allow assumption of thresholded genotoxic effects are also described
  • Risk Management: US and European regulations for chemicals
  • Toxicity of Chemicals: the toxic mechanisms and effects of major groups of chemicals

Toxicology and Risk Assessment is an essential text for scientists in academia, industry and government agencies who want to understand how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios.

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