Spyros studied Politics, International Studies and Sociology at Panteion University and, as a NATO postgraduate fellow, at the University of Kent. In 1994, he joined the University of Portsmouth as a Senior Research Fellow and, later, Senior Lecturer in International Politics. He worked to set up the Centre for European Studies Research and in 2000 he moved to Kingston University as a Senior Research Fellow where he launched an MSc in International Conflict which he also directed. As of 2012, he has been teaching and conducting research at the Center for Middle Eastern Studies of Lund University. He has been visiting professor on conflict analysis, nationalism and human rights at the University of Siena, nationalism and multiculturalism at Tartu University and Southeastern European Studies at Istanbul Bilgi University.
His research focuses on nationalism and ethnic conflict, protest politics in SE Europe and the Middle East, Muslim networks, communities and identities in Europe, populism and far right neo-populism.
He is member of the advisory board of Transconflict and has been chair of the Association for the Study of South Europe and the Balkans, of the editorial boards of the Journal of Area Studies, Mediterranean Politics and the Journal of Southern Europe and the Balkans and is editor of the Journal of Contemporary European Studies. He is currently co-editing a book series on Islam and Nationalism for Palgrave Macmillan.