I liked this one, unlike the other reviewer, although like him, I have only read Jim Butcher's novel of this series.
The key thing with Spider-Man is to get inside the character's head and to get his voice right, because its the Parker/Spider-man corss-over where the dilemmas and drama usually reside.
Here the plot is about new and bad drugs, not an original plot line, but still the subject of much real-life drama and hardly exhausted as drugs mask issues about control and responsibility. And when you're a teacher, like Mr Parker, its a cert you'll come across them in a rough social neighborhood. Here in St Albans, we have it easy.
So this one is a kitchen sink drama, and it does involve a lot of peripheral characters more than usual. But I personally like that, and warmed very much to by far the best exploration of the Spider-Man/police relationship. That was a much-needed examination and is very well explored on both sides of the argument. The villain here is almost an after-thought, but for all that, it is not wasted or thrown away totally. You feel with Spider-Man, usually, not everybody wins. There's the opposite of a silver-lining with his triumphs. That's a satisfying layer of real-life spread into the sandwich of his fiction - and DeCandido get this right, the voice and the pace right, to make an excellent addition to the novels about this fascinating and tormented character.