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Queen Victoria's Gene: Haemophilia And The Royal Family (Pocket Biographies) Paperback – 25 Mar 1999
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Queen Victoria's son, Prince Leopold, died from haemophilia, but no member of the royal family before his generation had suffered from the condition. Medically, there are only two possibiities: either one of Victoria's parents had a 1 in 50,000 random mutation, or Victoria was the illegitimate child of a haemophiliac man. However the haemophilia gene arose, it had a profound effect on history. Two of Victoria's daughters were silent carriers who passed the disease to the Spanish and Russian royal families. The disease played a role in the origin of the Spanish Civil War; and the tsarina's concern over her only son's haemophilia led to the entry of Rasputin into the royal household, contributing directly to the Russian revolution.
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I wish D.M. Potts would tackle the gene of the madness of George III!
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