Cellular and Molecular Immunology, 9e Paperback – 12 May 2017
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"This is one of the premier textbooks of immunology. It covers all aspects of immunology from the innate immune response to adaptive immunity, and their role in antimicrobial defense, autoimmunity, allergy, etc." Reviewed by Luis Sigal, DVM, PhD (Thomas Jefferson University)
An immunology textbook like no otherSee all Product description
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It covers each of the immune elements in detail and that includes the innate and adaptive system. Specifically:
1. The discussion of T helper cells is complete with an excellent summary and detail on each of its elements.
2. The CTL are covered in equal detail and these are critical in the understanding of current immunotherapy.
3. The complement system is covered but here I would have liked to see it more on a stand alone basis. The complement system gets limited coverage but recent work in AMD for adults seems to give it some potential.
4. Immunotherapy in a broader sense is covered but not in detail. For example there is limited inclusion of dendritic cell therapy for prostate cancer.
It is not clear what this is used for, since it is so encyclopedic. I have considered it akin to a "shop manual" for immunology. It has every part and piece and it details what part is connected to what other part.
However, the Immune System is a system and this system view is lacking. To understand immune system failures one must understand the basic dynamics of the immune system. This book detailed every piece and part but lacks leaving the reader with an overall system view. One can walk away with encyclopedic knowledge but not necessarily with a visceral understanding of the workings.
Not withstanding my critique, this is clearly the standard for such presentation. However theKuby Immunology series does add a dimension which is missing, namely the laboratory efforts involved in understanding where and how many of these facts were determined. I have used the Kuby books from the first addition forward and they are an excellent complement to this work. Also I have found the book by How the Immune System Works (The How it Works Series) is an excellent "road map" and system oriented book than can be used in conjunction with this one.
Overall this book focuses primarily on the immune system elements. However there are many underlying genetic pathways that play a significant role and these are not considered in any detail. For example, the impact on the NF-kB pathway is significant as a promoter of cytokine production. I would assume that one should be aware of its function and impact.
Overall this book is essential to have for anyone trying to do work in the current state of immunology. It provides the details and foundational elements that are invaluable. From this book one can jump quickly to the current literature.
Have every edition back to the first one.
Every practicing allergist-immunologist should have one.
Makes it easier to understand the basic immunology of how mAbs work.