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What Is Life?
on 8 September 2004
What Is Life?
Cambridge University Press (2002)
The structure of DNA and the genetic code may have alluded us for some time more if Crick had not read Erwin Schrödinger's "What Is Life?" . The research lead that Crick got by doing so was how a small set of repeating elements could give rise to a large number of combinatorial products, a mathematical relationship that Schrödinger illustrated using the Morse Code, based on an idea that he had actually got from the visionary work of Max Delbrück.
Delbrück, Schrödinger and Crick were physicists with an enthusiasm for tackling the unknown for the natural world. Crick's own motivation came directly from reading "What Is Life?" . It seemed reasonable to make the cross-over as the infant field of biochemistry was bound to be governed by the same chemical and physical laws revealed in other, non-biological, disciplines. This was especially true given the progressive focus of biology on the increasingly small, until an effective convergence of scales in the studies of the biologically relevant on the biologically irrelevant. Hence the justification for Schrödinger's unspecific book title.
Although some of the notions in the book have been superseded by modern science, this remains a classic, written with great insight and modesty (Schrödinger downplays his potential as a biologist), and is worth the read if only as a portal in to the minds of those luminary workers.
By the time Watson and Crick were piecing together the jigsaw that would lead to their grand discovery, the far-reaching potential of Schrödinger's code script had been aligned with Chargaff's finding of a variable sequence of nucleotide bases, and the stage was set for that immortal terminal sentence, "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material."
 Francis Crick (1989) What Mad Pursuit. Penguin.
 James Watson (1981) The Double Helix. Weidenfeld and Nicholson.