What a great bag for when you want to mix business with the ability to travel with your camera gear. Have had this for a couple of months now and use it as my day to day bag to travel to the office with my laptop (plus charger and mouse), notebook and other bits and pieces. I've also been on three business trips away from the office and each time the bag proved to be ideal. Ten day trip to Dubai allowed me to carry my normal day to day office stuff plus my Nikon D-80 plus 18-200mm and 10-24mm Nikkor lenses (both with lens hoods). On another trip to Italy I just carried my laptop with D-80 and 18-200mm lens. On a third trip to London, I decided that I did not need my camera gear but just my laptop and a spare short, trousers, underwear and wash kit for an overnight stop. On each trip the bag provided ample space and the ability to expand it to accommodate more gear by simply undoing the zip is really useful.
For any dedicated photography trips I'll still use my Lowepro Photo Sport 200 AW Backpack for Camera - Black
but when I need to travel on business with some camera gear while keeping my luggage to the minimum, the Up-Rise 38 is now my first choice.