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Supplements which work. A guide for the misinformed.


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Initial post: 31 Jan 2013 10:45:39 GMT
Last edited by the author on 31 Jan 2013 10:46:07 GMT
Coenzyme Q10 Stops 50% of Migraines

Coenzyme Q10 can stop migraine attacks in humans, according to a double-blind placebo-controlled study presented at the American Academy of Neurology annual meeting in April 2004.

The double-blind, placebo-controlled study involved 42 subjects who suffered an average of 4.4 migraine attacks per month. The patients were not allowed to take any other migraine medication during the study. For a month, all subjects consumed a placebo, and then some of the patients were randomly assigned to receive 100 mg of a liquid, water-soluble form of CoQ10 (Q-Gel) three times a day. The remaining subjects continued to receive a placebo.

Roughly 48 percent of the Coenzyme Q10 group experienced a 50% response rate during the three-month study. Only about 14 percent of those taking a placebo experienced the same response rate. In addition, the patients treated with CoQ10 experienced fewer migraine attacks per month-3.2 after treatment compared to 4.4 before treatment-while the placebo group experienced no reduction in migraine frequency. CoQ10-treated subjects also experienced more headache-free days than the placebo group and fewer days with nausea.

Although one subject developed an allergic skin rash after taking CoQ10, adverse effects were minimal. One of the researchers in the study pointed out that the mild and rare side effects that occurred with CoQ10 were mild compared to side effects that occur with anti-migraine medications such as beta blockers.

The study results confirm those of an earlier study of CoQ10 and migraines.

According to the researchers, the mechanism behind Coenzyme Q10's anti-migraine action may have to do with the mitochondria. They speculated that a decrease in mitochondrial energy reserve may cause migraines. CoQ10's ability to enhance mitochondrial function may be the mechanism behind its anti-migraine effect.

Comment by Alan R. Gaby, MD

Previous studies have demonstrated that migraine patients have impaired mitochondrial function resulting in a reduction in energy production in brain tissue. Nutrients essential for mitochondrial energy production include magnesium, riboflavin, niacinamide, CoQ10, [Carnitine, and Ribose].

Controlled trials have demonstrated that supplementing with either magnesium or riboflavin can reduce the attack rate in migraine sufferers. Niacinamide has not been studied for migraine prophylaxis. While there is a single case report in which niacin reduced the recurrence rate of migraines (Mayo Clin Proc 2003;78:770-771), the effectiveness of niacin may have been due to its vasodilatory action, which is not shared by niacinamide. An earlier uncontrolled trial showed a beneficial effect of CoQ10, and those results have now been confirmed in this double-blind trial.

Reference:
American Academy of Neurology 2004 Annual Meeting, San Francisco, April 28, 2004, Abstract S43.004.

Sandor PS, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology 2005;64:713-715.

Posted on 31 Jan 2013 11:01:45 GMT
To me, it seems reasonable to claim that some supplements 'work'.

I'm interested to know why you take 9,000 iu of vit D a day?

In reply to an earlier post on 31 Jan 2013 11:10:10 GMT
Last edited by the author on 31 Jan 2013 11:10:42 GMT
After reading three books with a huge volume of data I believe that it is a good winter dosage for maximum health. Remember D is a hormone, vital for gene expression. Like the use of 'to me' and the rabbit ears for work...well done....

In reply to an earlier post on 31 Jan 2013 11:11:20 GMT
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In reply to an earlier post on 31 Jan 2013 12:12:01 GMT
Would you describe yourself as being a chap in <<maximum health>>, for a chap of 53 pushing 54 that is?

In reply to an earlier post on 31 Jan 2013 12:13:54 GMT
I'm glad you noticed, I usually qualify what I write Simone.

In reply to an earlier post on 31 Jan 2013 12:40:31 GMT
Luddite Joe says:
After reading three books...
I remind you, S"TF"U Boyd, that nothing can be learnt from books.

In reply to an earlier post on 31 Jan 2013 15:22:25 GMT
Where do you spray it?

Have you noticed any change in your physical condition since taking 9,000 iu of vit D daily?

Posted on 31 Jan 2013 15:23:58 GMT
Spin says:
I think I will stick to a JD, coke, ice and lemon as my occassional "supplement".

Posted on 31 Jan 2013 16:04:05 GMT
J. Forbes says:
Statistically, a sample of 42 people is almost meaningless.

In reply to an earlier post on 31 Jan 2013 16:06:35 GMT
Dan Fante says:
42 is the answer to life, the universe and everything.

Posted on 31 Jan 2013 16:07:01 GMT
Spin says:
Statistics: the art of manipulating truth.

In reply to an earlier post on 31 Jan 2013 16:59:48 GMT
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In reply to an earlier post on 31 Jan 2013 17:00:24 GMT
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In reply to an earlier post on 31 Jan 2013 19:19:56 GMT
...going on 53

In reply to an earlier post on 31 Jan 2013 19:21:37 GMT
Yup....and feeling like Tony the Tiger...gggggrreeeeeeeeaaaattt!

In reply to an earlier post on 31 Jan 2013 20:46:32 GMT
Your pal Tiger on here?

Posted on 1 Feb 2013 10:46:31 GMT
Dan Fante says:
52? Is that in dog years?

Posted on 3 Feb 2013 20:07:01 GMT
Charlieost says:
What a busy life you have Simon. My missus brings me a cup of tea and the paper around eleven in the morning and I drink the tea, read a bit of the paper and then make some breakfast and take it back to bed with another cup of tea. At some point I might have a roll up to go with the paper. Eventually I get up depending on the weather or if anyone has texted needing a lift or a bit of work done.

This is only during the week though. At weekends I have a lie in. C
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Discussion in:  politics discussion forum
Participants:  7
Total posts:  19
Initial post:  31 Jan 2013
Latest post:  3 Feb 2013

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