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Mast Cells in Allergic Diseases: 87 (Chemical Immunology & Allergy)

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Mast Cells in Allergic Diseases: 87 (Chemical Immunology & Allergy) (Hardcover)

by Hiroshi Saito (Editor), Yoshimichi Okayama (Editor), Johannes Ring (Series Editor), L. Adorini (Series Editor), C. Berek (Series Editor), K. Blaser (Series Editor), Monique Capron (Series Editor), J. A. Denburg (Series Editor), Stephen T. Holgate (Series Editor), Gianni Marone (Series Editor)

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6 new from �121.55 3 used from �153.39

Product details

Hardcover: 218 pages
Publisher: S Karger AG (27 Jun 2005)
Language English
ISBN-10: 3805579489
ISBN-13: 978-3805579483
Product Dimensions: 24.4 x 17 x 1.5 cm
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Product Description

Product Description
The discovery of IgE and its association with mast cell histamine release provided the initial understanding of the role of mast cells in asthma and acute allergic reactions. However, mast cells are now recognized as tissue-dwelling effector cells that play multiple roles not only in immediate-type allergic reaction but also in innate immunity, inflammation, angiogenesis, and tissue remodeling. Mast cells produce a variety of lipid mediators, chemokines, cytokines, and enzymes that may interact with inflammatory tissues such as asthmatic lungs. This book focuses on the roles of mast cell products in allergic diseases and discusses strategies to regulate mast cell functions without perturbing their physiological roles. It also aims at understanding mast cells at the system level by creating a detailed model of cell regulation which is expected to lead to highly mast cell-specific, i.e. efficient and safe, drug targets.

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