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Transglutaminases: Family of Enzymes with Diverse Functions: 38 (Progress in Experimental Tumor Research)

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Transglutaminases: Family of Enzymes with Diverse Functions: 38 (Progress in Experimental Tumor Research) (Hardcover)

by K. Mehta (Editor), R. Eckert (Editor), J.R. Bertino (Series Editor)

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Product details

Hardcover: 254 pages
Publisher: S Karger AG (7 Mar 2005)
Language English
ISBN-10: 3805579012
ISBN-13: 978-3805579018
Product Dimensions: 24.4 x 17.3 x 1.5 cm
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Product Description

Product Description
Transglutaminases are a family of structurally and functionally related enzymes that are widely distributed and have been identified in a variety of organisms ranging from bacteria to mammals and plants. The reactions (isopeptide bonds) catalyzed by these enzymes are of great physiologic significance; they are highly stable and resistant to proteolytic degradation. Isopeptide bonds are commonly found in hair and skin, and they accumulate during wound healing, apoptosis, and blood clotting. Dysregulation of transglutaminase functions results in a number of pathologic conditions, such as neurodegeneration, autoimmune diseases, infectious diseases, progressive tissue fibrosis and diseases related to the assembly of the stratum corneum of the epidermis of the skin. The ability of transglutaminases to catalyze highly stable isopeptide bonds is also being exploited by the food processing and textile industries.

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