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The Pathological Protein: Mad Cow, Chronic Wasting, and Other Deadly Prion Diseases
 
 

The Pathological Protein: Mad Cow, Chronic Wasting, and Other Deadly Prion Diseases (Hardcover)

by Philip Yam (Author) "A new resident arrived at Dunstan House Nursing Home in early May, and he was clearly an anomaly ..." (more)
5.0 out of 5 stars See all reviews (2 customer reviews)
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Product details

  • Hardcover: 304 pages
  • Publisher: Springer (13 May 2003)
  • Language English
  • ISBN-10: 0387955089
  • ISBN-13: 978-0387955087
  • Product Dimensions: 23.6 x 16.3 x 3 cm
  • Average Customer Review: 5.0 out of 5 stars See all reviews (2 customer reviews)
  • Amazon.co.uk Sales Rank: 565,509 in Books (See Bestsellers in Books)
  • See Complete Table of Contents

Product Description

Review
From the reviews:

"The book is written for a general audience and is not necessarily targeted specifically to those in the medical field, according to the author. a ] This is an excellent book for the person who has a broad interest in prion diseases. It is well written and informative. I was impressed with the quality of the book and how easy it is to read. a ] I would recommend it to both physicians and lay people." (Leah D. Kroger, www.doody.com, February, 2004)

"Scientists still have more questions than answers about BSE, vCJD and the related scourges which make up the transmissible spongiform encephalopathies (TSEs). Philip Yama (TM)s book, a ~The Pathological Proteina (TM), does an admirable job of exploring them. a ] is full of such sensible observations, a welcome novelty in discussions on this fraught topic. The author is particularly good at explaining the complex and controversial science behind TSEs, as well as the prospects for better diagnosis and treatment a ] ." (The Economist a "online, March, 2004)

"Philip Yam, Scientific American writer and editor, has a knack for boiling down complex science and making it palatable to the general public. Yam demonstrates his skills in an important new book, The Pathological Protein. a ] His treatment is thorough, entertaining, and honest. a ] This is definitely a book for decision-makers to read and underline. a ] it is a sourcebook of extremely valuable information about TSEs and a guide to some very suspect areas of farming and meat producing." (James A. Swan, National Review Online, www.nationalreview.com, August, 2003)

"Yam, a writer and editor for Scientific American since 1989, presents a detailed yetreadable history of the mad cow scare and other prion diseases that affect humans and animals, such as scrapie. a ] Yam gives more coverage to the U.S. reactions to BSE and delves into the problems of chronic wasting disease (CWD) in elk and deer in North America and the research on other prion diseases like fatal familial insomnia (FFI). Recommended for most science collections." (Margaret Henderson, Library Journal, June, 2003)

"Yam, who has written and edited for the Scientific American has a singularly easy style to read and the story that he tells is of how the family in Devizes in England first found their son had variant CJD. a ] He writes this for a wide audience with it being interesting for everyone from the scientists to the average reader and he includes large amounts of information a ] . A book aimed at a very wide audience but scientifically involving." (Stephen Dealler, priondata.org, August, 2003)

"When bovine spongiform encephalopathy (BSE) first appeared in 1986 in the UK, many of the worries focused on the countrya (TM)s agricultural industry a ] . Much of the literature on the subject tells the story of how we gradually realized that maybe humans were at risk a ] . In his well-written and easy-to-understand book a ~The Pathological Protein a ] Philip Yam paints a different picture. a ] Anyone who reads Yama (TM)s excellent book will understand how data on TSEs were in fact readily accessible during the past 20years." (Stephen F. Dealler, C&EN - Chemical & Engineering News, November, 2003)

"It is indisputable that interest in the rare and unusual greatly exceeds that given to the common and mundane. The appearance of yet another book on transmissiblespongiform encephalopathies (TSEs) should not therefore be surprising a ] . All this suggests that writing a book about TSEs should be easy. How was it for Philip Yam? In The Pathological Protein a ] he does a good job. a ] his accounts of technical matters are reader-friendly, but do not dumb down. a ] It is comprehensive, well researched and well referenced." (Hugh Pennington, Times Higher Education Supplement, December, 2003)

Product Description
Prions are an entirely new class of pathogens, and scientists are just beginning to understand them. This book tells the strange story of their discovery, and the medical controversies that swirl around them.

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Inside This Book (Learn More)
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A new resident arrived at Dunstan House Nursing Home in early May, and he was clearly an anomaly. Read the first page
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Customer Reviews

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3 of 3 people found the following review helpful:
5.0 out of 5 stars Easily the best book of its kind, 7 Oct 2003
By S. C. Macdiarmid (Wellington New Zealand) - See all my reviews
(REAL NAME)   
Philip Yam's book The Pathological Protein is easily the best book of its kind. Written in clear, simple language for the non-specialist audience, The Pathological Protein is a thoroughly comprehensive, concise and, above all, scientifically accurate review of BSE and related diseases. Yam has been writing and editing for Scientific American since 1989 and this, his first book, demonstrates the high standard to which all science writers ought to aspire.

The first chapter of The Pathological Protein describes, from a very human perspective, the effects of variant Creutzfedt-Jakob disease on one victim, 19 year-old Stephen Churchill, and his family. From this tragedy, Yam then goes on to review the history of CJD and the mysterious diease 'kuru', which reached epidemic proportions amongst the Fore people of Papua-New Guinea because of their cannibalistic funerary rites. After discussing the hereditary transmissible spongiform encephalopathies (TSEs) of humans, outlines what is known of the TSEs of animals. Philip Yam's reviews of scrapie, BSE, transmissible mink encephalopathy and chronic wasting disease are up-to-date, interesting, and extremely readable.

There is an interesting episode related in the book. Carlton Gajdusek had been searching, unsuccesfully, for the cause of kuru. William Hadlow, and American scrapie researcher on a secondment to the United Kingdom, visited the Wellcome Medical Museum in London to look at a display on kuru that Gajdusek had prepared. It was Hadlow who first noticed the very close resemblance between kuru and scrapie. The similarities in epidemiologic features, general clinical pattern and the neurohistologic changes led him to the realisation that these diseases were probably mmebers of the same family. As a result of Hadlow's insight transmission experiments were started which, eventually, led to our current understanding of the TSEs

This book covers the hypotheses for the origins of BSE, the evidence for the link between BSE and vCJD, current methods and problems of diagnosis of the TSEs, and the search for cures. Philip Yam clearly is thoroughly versed in the scientific literature of the TSEs, but also interviewed a broad range of scientists, consumers advocates and regulators. So, he knows what he is writing about, and this is made evident by the clarity and accuracy of his explanations. Although there is no 'dumbing down' of a difficult and complex subject, the author has written a book which makes his subject easily accessible to the non-specialist reader. The book is referenced, well indexed, has a useful glossary and also suggests sources for further information, including the more useful web sites and organisations providing suport and help for families of CJD victims. While the book is written for the interested lay person, I would have no hesitation in recommending Philip Yam's The Pathological Protein to veterinarians and colleagues who want an interesting, thorough and current review of these fascinating diseases.

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2 of 4 people found the following review helpful:
5.0 out of 5 stars A view from a relative of a vCJD victim, 18 Sep 2003
By Mr Graham Steel (Scotland, UK) - See all my reviews
I was first alerted to this book about 3 months ago. I have read most of the book now.
The reporting within the book is remarkably accurate and up to date. It pulls in so much information from across the world of the, still, many uncertainties re. TSE issues.
I have sadly learned yesterday of another vCJD victim (alive) in the US. The individual has never been to the UK.
The relavence of this book is of upmost importance if we are to unravel the many unknowns of CJD/BSE and also CWD.

I lost my brother to vCJD in 1999. I am currently Vice-Chair of Human BSE Foundation here in the UK. In essence, we are a support group.
We recently travelled to the US, to "tell or story" at a CJD Conference. We are now working with many other similar Organisations to tackle these outstanding issues. We must campaign globally, if we are so stand any chance in our campaign.

We therefore welcome the importance of The Pathelogical Protien for a number of reasons. The more that people learn accurately about all of this the better for us all.

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