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Now in its third edition, Human Molecular Genetics continues to provide authoritative guidance on the principles underlying human molecular genetics. The content and organization has been fully revised.
From the Back Cover
With this fully updated third edition, Human Molecular Genetics enters the post-genome era. The content and organisation have been thoroughly revised to take account of the new knowledge and new emphases in human molecular genetics now that we have the human genome sequence.
Introductory chapters cover DNA structure and function, chromosomes, pedigrees and the basic techniques of PCR, cloning and hybridization, and now include a new chapter on cells and development. Later chapters detail our new understanding of the structure, organization, expression and evolution of the human genome, and the progress of the many parallel genome projects.
Sections on variation, mutation and disease relate this knowledge to Mendelian diseases, complex multifactorial diseases and cancer. Mapping and identification of disease genes, molecular pathology and molecular diagnosis are treated in depth. The final sections cover functional genomics, the role of animal models and new approaches to genetic treatment of disease.
Overall, Human Molecular Genetics provides a complete, up-to-the-minute account of human molecular genetics in the post-genome era, from basic principles to current practice. Human Molecular Genetics is carefully designed to engage and motivate students with clear yet detailed full-colour illustrations, special topic boxes (including coverage of ethical, legal and social issues such as eugenics, genetic testing and human cloning) and a constant emphasis on understanding principles rather than learning detail.
Introductory chapters cover DNA structure and function, chromosomes, pedigrees and the basic techniques of PCR, cloning and hybridization, and now include a new chapter on cells and development. Later chapters detail our new understanding of the structure, organization, expression and evolution of the human genome, and the progress of the many parallel genome projects.
Sections on variation, mutation and disease relate this knowledge to Mendelian diseases, complex multifactorial diseases and cancer. Mapping and identification of disease genes, molecular pathology and molecular diagnosis are treated in depth. The final sections cover functional genomics, the role of animal models and new approaches to genetic treatment of disease.
Overall, Human Molecular Genetics provides a complete, up-to-the-minute account of human molecular genetics in the post-genome era, from basic principles to current practice. Human Molecular Genetics is carefully designed to engage and motivate students with clear yet detailed full-colour illustrations, special topic boxes (including coverage of ethical, legal and social issues such as eugenics, genetic testing and human cloning) and a constant emphasis on understanding principles rather than learning detail.
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