Vampire is one of the most flexible games out there, lending itself well to politics, intrigue, investigation, high drama, horror and fights that wouldn't be out of place in the Matrix or Kill Bill. As a vampire you are an undead monster that now feeds from the people you used to be, whilst still pretending to be human. Question is, can you keep your monstrous urges in check, bend them to your will or will your thirst just consume you?
The D10 system is very straightforward and intuitive, involving nothing more than counting, and allowing for varying degrees of success. The pairing of an attribute and an ability is easy to 'guess' on the fly when you don't want to interupt the flow of the game and look in a rule book. You definitely don't need a spreadsheet to keep a track of everything.
Although this book is all you need to play the game, there a lot of source books out there to provide inspiration. All of them, including this book, are full of gorgeous artwork and small snippets of fiction to help immerse you into the atmosphere.