I remember the first Vonnegut I ever read: Cat's Cradle, read in 8 hours on a flight from London to Dallas when I was 14. It was unlike anything I had ever read before or have read since, Vonnegut's other novels included. But this book brought back the excitement of that first discovery.
Timequake is, as far as I am concerned, his best novel. Touching, funny, surreal, quizzical, elegiac, dismissive, pointless, asinine, glorious, weird, wonderful. I've run out of adjectives. Let's hope he can think of some more before he snuffs it.
Incidentally, if you're worried Kurt will pop his clogs and you'll have nothing to read, may I highly recommend Bo Fowler who seems to be making a brave stab at taking over his mantle.