There aren't that many tragedy plots in the Renaissance but this one really is different. The traditional elements of love-revenge are all there but re-arranged into quite a different pattern. With a particularly strong role for Evadne this overturns the more usual conventions and genuinely feels fresh and surprising.
The intersection between sex and politics is particularly interesting here (though not especially innovative) especially the idea of regicide in the generation before Charles I.
Most of all, I found this genuinely emotionally potent, especially the characters of Amintor and the two women. So a less canonical Jacobean tragedy but one which perhaps deserves more attention.