Honestly, one of the best books I've read. Randy Paush not only has something unique and important to say, but the way he has chosen to say it is amazing. I'd rank this book, inspirationally, with THE POWER OF NOW and TUESDAYS WITH MORRIE.
Here's the idea of the book: Non-fiction, it is the account of Pausch's "last lecture" which he gave at Carnegie Mellon. Pausch was diagnosed with pancreatic cancer and given a few months to live so he decides to make some changes in his life--quit his job, be with his family. The title comes from the idea that at Carnegie Mellon, retiring professors are aked to give a "last lecture." So the title is ironic and a play on words in a sense.
While the lecture is for everyone, Pausch really did this for his kids, who were too young at the time to know what was going on. It is so inspirational and its basic premise is that we should get all we can out of life now. I also enjoyed LIFE BEYOND MEASURE: LETTERS TO MY GREAT-GRANDDAUGHTER which is somewhat along the same lines as THE LAST LECTURE in that it was what Poitier wanted to leave behind to his great-grandaughter who is too young to really understand things right now.
If you're looking for an inspirational book, and one that will keep you up at night thinking about how to live your life, THE LAST LECTURE is the non-fiction pick for you.