I cannot find words for how good The Confusion is. We still follow the people from Quicksilver as they strive to find their way in the chaotic world of the late 1600's and early 1700's. The themes are still money, piracy, sex, slavery, science, black magic, etc. and the cast is still comprised of vagabonds, galley slaves, scientists, royalty, soldiers, priests, alchymists and much, much more. The action goes (literally) round the world, to places like Egypt, India, Japan, the Philippines, all of Europe and, of course, Qwghlm, the fictional Island that also appears in Cryptonomicon.
I am in awe of how many themes are woven together in this book, and of the amount of research it must have taken. I have never had any sense of what the rennaisance was like, and suddenly the 1600's seem real and present to me. I've done some fact-checking in Wikipedia, and it only serves to expand and deepen the picture that Stephenson paints of that period.
The ending is just about the funniest, saddest, most satisfying, most intriguing and most annoying thing I've ever read. And I can't wait to read the final book in the series which is The System of the World.
A word of caution: These books are subtle. Much of the actions is hinted at rather than described explicitly. Once you get the hang of it, it is immensely satisfying to read.