I found the author's argument unconvincing. I think Kramer's "Listening to Prozac" paints too rosy a picture, while "Talking Back To Prozac" is way too negative. I think the truth is somewhere in between. The comment the author makes repeatedly in the book about the "sick" people who seem to like Prozac is not open minded, and reveals the religious intensity of the author's opposition (I am not taking Prozac!). The close minded arguments of the author turned me off, and I could care less about the bureaucratic problems of the FDA. The truth about depression and the effectiveness of the SSRIs is independent of the FDA's Prozac drug trials, and dumping on a very large part of the medical community because of a strong feeling against SSRIs was not at all convincing to me, and made for an unsatisfying read. His linking of SSRIs to amphetamines seemed very unscientific to me, and he did not reveal how he came up with this conclusion to my satisfaction. I would appreciate a more clinical proof of SSRI ineffectiveness, and would not accept his word for it just because he believes strongly about his point of view. Two words to describe this book is: Too extreme. I disliked this book alot.