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Structure and Mechanism in Protein Science: Guide to Enzyme Catalysis and Protein Folding Hardcover – 15 Feb 1999


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Product details

  • Hardcover: 600 pages
  • Publisher: W.H.Freeman & Co Ltd; 3rd Revised edition edition (15 Feb. 1999)
  • Language: English
  • ISBN-10: 0716732688
  • ISBN-13: 978-0716732686
  • Product Dimensions: 16.1 x 3.6 x 23.9 cm
  • Average Customer Review: 4.0 out of 5 stars  See all reviews (2 customer reviews)
  • Amazon Bestsellers Rank: 534,157 in Books (See Top 100 in Books)
  • See Complete Table of Contents

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8 of 9 people found the following review helpful By A Customer on 29 July 2003
Format: Hardcover
Fersht’s ‘Structure and Mechanism in Protein Science’ covers the broad spectrum of Protein Chemistry chiefly from the view of a Biophysicist. That is to say, it only briefly describes proteins in a manner easily understood to a newcomer to peptides – Branden and Tooze’s ‘Introduction to Protein Structure’ should really be a first port of call if this area of Biochemistry is unfamiliar to the reader. The real strength of the textbook is in the clarity of explanation of enzyme catalysis – a very multifaceted subject – from a physical viewpoint. The construction of arguments from simply explained principles is a common theme throughout these many chapters on catalysis and the terminology will be recognisable for anyone with a basic grounding in Physical Organic Chemistry. Those acquainted with the style of Sykes ‘Guidebook to Mechanism in Organic Chemistry’ will be in familiar territory here.
‘Structure’ contains many examples of enzymatic function to describe the various processes involved in enzyme specificity and mechanism that the reader will find useful without being overwhelming, unlike so many other Biochemistry textbooks. It appears that Fersht has selected his examples to explain a point rather than to be a comprehensive overview of catalysis. In addition, there are very useful accounts for the researcher in how to obtain such information by the way of applying the model or equations given to a real-life system.
In addition to the enzymatic structure and function that constitutes the bulk of the book, there is a concise account of Protein Engineering for both enzyme function study and protein stability itself.
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Format: Hardcover
More detailled version than the original Ferscht.. All the basics, very useful!
Quite old though (1998), could use some updating
Book in very good shape
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Most Helpful Customer Reviews on Amazon.com (beta)

Amazon.com: 10 reviews
49 of 50 people found the following review helpful
A classic - one of the "top ten" books for biochemists ! 20 Dec. 2000
By Doc Bailey - Published on Amazon.com
Format: Hardcover Verified Purchase
This book belongs in every protein biochemists collection. It is a clear, up-to-date review of protein structure and function, with a concentration on enzymes. It covers a host of vital topics, including: the theories of chemical catalysis, enzyme kinetics (buy Segal for an in-depth study of this topic), the methods for determining rate constants, the stereochemistry of enzyme reactions, various regulation mechanisms, binding energies and the forces between molecules, and an overview of protein engineering techniques. If all this were not enough, Fersht concludes with a wonderful chapter covering case studies of enzyme structure and mechanism, and another couple on the kinetics and mechanisms of protein folding. Extensive references are given to the current literature for further study.
Putting all these topics into one book is an accomplishment that few authors could pull off - but Fersht does it extremely well!
Oh - the other nine ?
Cornish-Bowden, "Principles of Enzyme Kinetics"; Segal, "Enzyme Kinetics"; Voet & Voet, "Biochemistry"; Branden & Tooze, "Introduction to Protein Science"; Dixon & Web, "Enzymes"; Pauling, "The Nature of the Chemical Bond"; Scopes, "Protein Purification"; Freifelder, "Physical Biochemistry"; Walsh, "Enzymatic Reaction Mechanisms"
18 of 19 people found the following review helpful
Biochemists Can't Miss 23 Aug. 2001
By Matthew M. Yau - Published on Amazon.com
Format: Hardcover
The book focuses on enzyme catalysis, stereochemistry of enzyme reactions, determination of rate constant, enzyme kinetics, and protein structure and folding. It would be an ideal reference for the study of protein chemistry. It can serve as the primary text for an advanced course in protein chemistry or a supplement for undergraduate biochemistry text.
Protein folding has remained one of the most intricate yet less understood process in modern biochemistry. Feersht's treatise of the subject in this book is splendid. The author overviews protein structure and diversity in the opening chapter. What I find really precious about this book is the discussion on protein engineering, forces on folding, and recombinant DNA technology in the context of protein folding.
Aside from protein chemistry, the chapter on chemical catalysis is excellent in learning more about transition state theory, general acid/base catalysis, covalent catalysis, structure-reactivity relationships, and kinetic isotope effects.
9 of 11 people found the following review helpful
essential 1 May 2002
By "tyrofox" - Published on Amazon.com
Format: Hardcover
If you are studying protein structure, you probably should read this book for reference.
This is solely my opinion, but I have learned new things and reinforced some old knowledge, as well. The book is well-written, and understandable, without being simplistic.
Some texts are difficult to understand, or dry, or facile. This is not one of those texts.
4 of 6 people found the following review helpful
Highly recommend it 31 Aug. 2003
By A Customer - Published on Amazon.com
Format: Hardcover
Hands down the bible of enzyme kinetics!
Anyone looking to learn more about enzyme kinetics, thermodynamics, structure, and function will find this book clear, thoughtfully written, and at the forefront in the field.
comment about the book Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding 27 Sept. 2012
By Beatriz - Published on Amazon.com
Format: Hardcover Verified Purchase
The book arrived fast and in a good quality.
The cover and the pages are clean and without any scrawl.
I am really enjoying my new book.
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