This clearly written little book documents what little is known about the psychoactive effects of the main drugs used in clinical psychiatry. As a clinical psychologist rather than a medic I cannot comment on the medical accuracy or potential bias of Dr Moncrieff's work. What I can say is that the book was very helpful in helping me understand the effects on my patients of the medications they take, i.e. what to expect by way of sedation, side effects and withdrawal effects.
Dr Moncrieff starts by outlining her drug-centred versus disease-centred approach to psychiatric medication. In practice this means questioning the idea that psychiatric disturbances are neurochemical imbalances which can be treated by the relevant 'anti' medication (e.g. antidepressant, antipsychotic). Once freed from this widespread, disease-oriented, lens we are freed up to consider psychiatric drugs as we would any other psychoactive drug: as compounds which may be sometimes be useful for (in particular) their sedating effects.
Particularly interesting were the two observations that: i) the neuroleptically aggressive approach to 'early intervention for psychosis' may be misleading since the research which finds early treatment leading to better outcome may be misinterpreting the fact that people who experience an acute (rather than protracted) onset (and who therefore present more quickly for treatment and accordingly have a shorter duration of untreated psychosis) tend to recover better anyway; ii) drug trials which compare staying on a drug with stopping taking it, and finding that more relapses occur in the second condition, may be mistaking an allegedly helpful 'disease-combatting' property of the drug for the rather different effect that suddenly stopping taking a psychoactive drug can create illness-mimicking or illness-causing withdrawal effects.
Chapters in the book consider 'anti-psychotics' (typically used for treating schizophrenic conditions), 'anti-depressants' (for depression), 'mood stabilisers' (for bipolar disorder), stimulants (for ADHD), benzodiazepines (for a range of problems), withdrawal, mechanism of drug action, drug- versus disease-centred models of medication and illness.