Lilo & Stitch follows the story of an orphaned Hawaiian girl, Lilo (Daveigh Chase), who lives with her 19 year old sister, Nani (Tia Carrere). The two girls have been struggling to make it on their own and things aren't going particularly well. When Cobra Bubbles (Ving Rhames), a no-nonsense social worker, drops by for a home visit, he finds the sisters in a middle of an argument and the house in a shambles. He warns Nani she has three days to prove she's an appropriate guardian for Lilo or the situation will have to change.
In the meantime Stitch, a mischief -making alien (officially known as Experiment 626) has escaped from the planet Turo and has crash landed on Earth. Stitch is bulletproof, fireproof and thinks faster than a supercomputer. He can see in the dark and move objects three thousand times his size. His only instinct is to destroy everything he touches. Posing as a small strange-looking "dog," Stitch is adopted by Lilo and leaves a wide path of chaos in his wake, proving to be the least affectionate pet on the planet. But through her love, faith and unwavering belief in Ohana" (the Hawaiian word and concept for family), Lilo helps unlock Stitchs heart and give him the one thing he was never designed to have a family.