I was very kindly bought the PRS-300 for Christmas by a number of family members who clubbed together to purchase it for me. The build quality of the hardware is excellent, and after reading a number of reviews it seems that this is the best model of the current generation, as the more expensive touch-screen models suffer from an inferior display, due to the touch-screen membrane laid over the screen.
Having read quite a number of reviews of these products, I didn't even bother trying to install the Sony software that shipped with the device, and instead downloaded 'Calibre' Ebook Management software, which is free software that supports the Sony Readers. This software worked perfectly with the Sony Reader and there are versions for Windows, Linux and Mac, so pretty much everybody should be catered for.
I've read 3 books on the device so far, and the battery is still at 3/4 charge, so I'd have no concerns over taking it away for a week without a charger.
The only criticism I can level at the device is that it isn't a real book and doesn't have the feel of a book. It would be churlish to mark it down for that, this device has given me the ability to slip a small library into my jacket pocket and carry it around with me.
It's a marvel.