My Sister's Keeper [DVD] [2009
I loved the book so much that I was not sure whether I wanted to see the film - however it is excellent, extremely well acted and directed. The ending of the film was different from the book, but it was logical and didn't detract at all.
Kate is sick, and her parents have an IVF baby, Anna, as a genetic match for Kate so that Anna can donate blood, bone marrow, whatever is necessary to save her sister's life. Eventually Kate becomes sick enough that Anna is expected to donate one of her kidneys to her sister, and she turns to a lawyer to gain medical emancipation from her parents.
Truly superb acting by all. Sofia Vassilieva was splendid as Kate, and Abigail Breslin as Anna. Cameron Diaz, as a fraught mother doing her best to keep her daughter alive by any means, is totally believable - so good to see her in a more stretching role than usual. Alec Baldwin as the lawyer, with health problems of his own, was inspired.
I first watched this in the cinema, and the whole audience was totally caught up in the emotions of the characters - the only sound was quiet sniffling. Very moving and definitely worth watching again.