This book is a concerted multi-author attack on a well known book, by Denis Alexander: "Creation or Evolution: Do We Have to Choose". Despite the unity provided by the single enemy, the book is very diverse, covering a broad span of theological and scientific subjects, and with chapters of unequal merit. I here focus on just the two chapters on molecular genetics, by Geoff Barnard. I would have preferred not to give a star-rating, because I do not feel competent to review all aspects of the book, but the Amazon website requires one. Therefore, in view of the faults of Barnard's chapters, and some other weaknesses that I notice at a more superficial level, I give it only two stars.
The two chapters by Geoff Barnard have a common aim: to refute the claim that man and higher apes have a common ancestry. In my opinion both chapters are seriously inadequate, for the reasons that follow.
Chapter 9C ("Chromosome Fusion and Common Ancestry"), the first of Barnard's two chapters, deals with the claim of Alexander (and virtually all evolutionary biologists) that DNA sequences provide strong evidence that chromosome 2 of humans was formed by the fusion of two ancestral chromosomes that persist in chimpanzees and other modern apes (designated 12 and 13, or in modern papers 2p and 2q). Alexander's argument is that chimpanzee chromosome 2p is strongly homologous with one part of human chromosome 2, that chromosome 2q is strongly homologous with the other part, and that the joining region in humans contains telomere sequences that would normally be at the end of a chromosome but are found in the middle of human chromosome 2, exactly as one would predict from the chromosome fusion hypothesis. Barnard accepts all of this! And he agrees that human chromosome 2 was formed by the fusion of 2p and 2q. All he does to contradict Alexander is to bring up three marginal questions. First, he mentions some difficulties to do with "alphoid sequences" that seem to me irrelevant in view of the fact that he accepts the chromosome fusion. Second, he mentions "human-specific" inversion in chromosomes 1 and 18, but I fail to see the relevance of this to the chapter's theme of chromosome fusion or more generally to the thesis of common descent. Then, finally, in the very last sentence he writes "What is certain, however, is that the wide variety of chromosome variations that clearly exist between the human and chimpanzee, dictate against the thesis that these species have common ancestry." This last sentence amazes me, partly because the chromosome variations are rather small (2% at the DNA sequence level), and even more so because Barnard has said almost nothing about the size of the variations in his chapter.
Chapter 10 ("Does the Genome Provide Evidence for Common Ancestry"), the second of Barnard's chapters, deals with the whole range of genomic data that Alexander presents as evidence for common descent: pseudogenes, mobile genetic elements and retroviral insertions. For brevity I here focus on the latter. When retroviruses infect a cell, they insert their DNA in the genome of the host cell, and the cell's descendants are thereby labeled recognizably from the presence of the retroviral sequence at a very precise place in the genome. When the cell is a germ cell, all the progeny are thereby labelled. Remarkably, the pattern of labelling is exactly what we would expect from a standard evolutionary picture. Thus, some insertions occur only in humans, others in humans and chimpanzees but not other primates, others in all primates, and so on. But you never find, for example, an insertion in humans and macaques but not chimpanzees. All of this is very strong, and direct, evidence for the common descent of humans, chimpanzees and other primates, and it presents a major problem for anti-evolutionists. Barnard's solution is to accept most of the data but to explain it away by claiming that particular retroviral sequences go very specifically to a precise location in the DNA. Thus, he claims (without evidence) that the presence of the same retroviral DNA sequence at EXACTLY the same location in chimpanzees and humans is due to the fact that one virus infected a chimp germ cell, another infected a human germ cell, and their identical sequences went to identical places in the genome. Such amazing precision is not biologically credible. An enormous amount of research has been done on retroviral infections, and all the evidence is against Barnard's claim. It is true that the distribution of retroviral insertions is not totally random. Some tend to go near active genes, others near inactive ones, etc. But in claiming a "very precise" specificity in retroviral insertion location Barnard is misleading the reader very seriously. Without this blatantly false claim his case collapses.
Whatever may be the merits or faults of the other chapters, those on molecular genetics are seriously misleading.