I wouldn't like to say for certain as I'm currently trying to decide for myself. It seems that there are pros and cons for both. Rock Band is missing the customisable and downloadable content on the Wii that you'd get from the other consoles or from Guitar Hero World Tour, and it has wired drums (by the sounds of it). However, from reviews that I've seen, it seems that the guitars from Guitar Hero have a tendancy to break. Other than that, the choice seems to be mainly in the track list. Guitar Hero has a more general, perhaps more mainstream selection, but Rock Band is far more rock music style, verging on metal. Hope that helps.