I read Wittenborn's last novel, Fierce People, some years back and loved it: a no-holds-bared pacy version of The Great American Novel, with a rich narrative that stayed (just about) this side of melodrama, I'm pretty sure I read it in one sitting. I'd begun to wonder what had happened to him (it was about six years ago now) and Pharmakon gives us the answers.
If John Irving had a bit more edge and slightly less in the way of sentimentality, he might have written Pharmakon. Much like Fierce People it has a brilliantly pageturning plot (which I discovered in a piece in yesterday's Times is based, unfeasibly, on the author's life) but it's a much more grown up, emotionally considered piece of writing. It's a little like Jay McInerney, but with more likeable characters; a little like Brett Easton Ellis, but without the snarling cynicism. A little Tom Wolff, perhaps, but more generous-spirited and funnier. Wittenborn gives us an amazing portrait of family life (albeit a pretty dysfunctional family) in 1950 America and then takes the protagonist, Zach, on a compelling journey as he slides inextricably into drug addiction and personal crisis. On the way we meet some wonderful characters, not least Caspar, the sociopathic guinea pig who tries to kill Zach's family. There's a wonderful sense of redemption at the end of the novel, but it never feels forced or pat.
I'd have to say, this is one of the best books I've read in a good few years! For anyone who's a fan of modern American literature and great storytelling, it's a must.