Not only the best Perl book I've ever read, it's also one of the best programming language books, period.
If you've ever programmed C++ or Java, you'll know how revered the likes of Effective C++ and Effective Java are, a series of tips, suggestions, idioms, advice and commandments. This is the equivalent for Perl, except it's even more thorough and covers even more ground, from brace layout and statement formatting, to regexes, unit testing, documentation and command line parsing.
There's also an exceptionally good chapter on object orientation, wherein author Damian Conway guides the reader through the use of his own Class::Std module. If you're using objects in Perl, and you're still rolling your own, you're really making life unnecessarily difficult for yourself. Class::Std provides object features reminiscent of CLOS, and makes Perl competitive with the likes of Python and Ruby when it comes to objects. Class::Std has changed the way I code Perl forever, and I know I'm not the only one. Seriously, this chapter is worth the price of admission on it own.
It's hard to overstate just how much excellent stuff there is in here, there's even useful emacs and vi settings provided! And I've not even mentioned how well written it is. Damian Conway really does prove himself the master of witty examples.
Perl Best Practices is just brilliant. Absolutely essential reading - don't code Perl without it.