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This book is suitable for advanced undergraduate students, researchers and professional chemists. Both the writing and the diagrams are simple and clear. ( Reviews, May 2009)
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Organic Synthesis: The Disconnection Approach, 2nd Edition introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.
Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given.
This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, “Organic Synthesis: Strategy and Control”.
Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.
Organic Synthesis: The Disconnection Approach, 2nd edition provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.
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E.J. Corey (Noebl prize winner in organic chemistry) first described a formal methodology for the retrosynthetic analysis in the 70's. That is, he described a strategy in which '(retro)synthesis patterns' could be applied. This was great work and others started to think in the same fashion after Corey published his ideas. However, the field really took off after the publication of this book in 1982. The reason for this is that Warren was able to teach others how to use(!) the retrosynthetic methodology. He did this by: 1) Knowing the skill level of his audience (3rd level univeristy student + post-graduate) 2) Highly structuring the material so that the reader progressively develops an understanding of the subject; and very importently 3) provide a number of very clear and useful examples (and an associated workbook completely filled with worked examples).
A great way to learn about this detailed subject. A classic!
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