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"...this text is directed towards graduates who are embarking on a career in medicinal chemistry in the discovery laboratory. Sliverman continues to blur the edges between chemistry and pharmacology in a manner that is incontrovertibly relevant to the discipline of drug design and development." -Michael E. Cooper, GE Healthcare, The Maynard Centre, in DDT, VOL. 9, 2004 "What stands out in comparison with other books discussed here is that the subjects are generally addressed in detail, and each theoretical point is illustrated with examples of specific drugs. A great deal of knowledge is reflected...that is suitable for both advanced students and PhDs a like who have not yet become acquainted with the area, but who wish to prepare themselves for a career in drug research." -ORGANIC CHEMISTRY ORG., 2005 Praise for the First Edition: "This book is a tour de force in the title area...This book would be appropriate for advanced undergraduate students and graduate students...strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration." --JOURNAL OF THE AMERICAN CHEMICAL SOCIETY "... unified, well-organized and clearly presented ...It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline." --Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION "The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way..." --William C. Groutas, WICHITA STATE UNIVERSITY "I was favorably impressed with the clarity of Dr. Silverman's writing style which made the material interesting and easy to read...Treatment of the material is quite comprehensive without being overly detailed and the referencing and illustrations are well chosen..." --John G. Topliss, PARKE-DAVIS "...The organization of this book and the clarity of presentation are outstanding... It is highly recommended to medicinal chemists as well as to all others entering into the field or concerned with the science of medicinal chemistry." --JOURNAL OF MEDICINAL CHEMISTRY Praise for the new edition: "...intent of the first edition was to provide a textbook for advanced undergraduate students or graduate students, the scope of the second edition has been expanded so that it not only serves the original purpose but also serves as an excellent reference book for practicing medicinal chemists." --John W. Ellingboe, Wyeth Research for the Journal of Medicinal Chemistry, 2004 "...this book is a thorough overview of drug discovery and development... It is not only an excellent textbook for students but also a valuable resource for those already practicing medicinal chemistry." John W. Ellingboe, Wyeth Research for the Journal of Medicinal Chemistry, 2004
Product Description
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and now includes color illustrations, chapter problems, and other elements that make concepts easier to understand. It gives an organic chemist's perspective of how drugs are designed and function and teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples. It features: extensive use of references to the primary and secondary literature for more in depth reading about all concepts; extensive use of structures, schemes, and figures to illustrate points; explanations of dual-acting drugs; problem sets and answers for each topic; and, casual writing style. The author has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.
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Front Cover | Copyright | Table of Contents | Excerpt | Index | Back Cover
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Front Cover | Copyright | Table of Contents | Excerpt | Index | Back Cover
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Most Helpful Customer Reviews
4 of 4 people found the following review helpful
Format:Hardcover
Although I am a student of biochemistry I found this book extremely useful when attending courses on drug design. This was particularly useful as I did not have a background in pharmacology to start with but this is not a requirement in order to understand this book. A basic knowledge of organic chemistry would be useful though. In summary a very clearly written book with good structures included to assist understanding of the topics. Excellent job!
3 of 3 people found the following review helpful
Format:Hardcover
If you are thinking of a career in medicinal chemistry/pharmacology or are already in involved in the chemistry of drug design then this is the book for you! This book is so clear, ideas are well explained and figures superb. With just a basic knowledge of chemistry you can easily get through this book and what an enjoyable read it is. I haven't seen anything close to this book on the market. I passed my drug design course module at university with flying colours thanks to this book. Superb!!!
3 of 3 people found the following review helpful
Format:Hardcover
This book was recommended to me for an introductory drug design course. I am glad I bought it since it really helped me get through what would have otherwise been a struggle. It outlines and goes into some detail about the drug design process and clearly describes the mechanisms by which enzymes work and drugs are metabolized. Also a bonus were the chapters on drugs that interact with DNA and also on prodrugs. Some knowledge of basic organic chemistry would be an advantage before reading this book.
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Most Recent Customer Reviews
Excellent textbook for Medicinal Chemists
As a PhD student doing medicinal chemistry project, this book gives me a novel insight into this exciting area. Read more
Published on 29 April 2009 by Zhiyong Yu
Brilliant Introduction to Medicinal Chemistry
For students who are planning to study medicinal chemistry/pharmacology this is an excellent introduction to the field. Read more
Published on 22 April 2001
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