For a long time I suffered from depression, at times very severe and incapacitating, and some 4 years ago finally and extremely reluctantly resorted to anti-depressants (SSRIs). Then someone recommended this book to me. Reading the chapter on depression revealed that my diet lacked certain nutrients important to mood, despite being basically healthy (vegetarian, wholefood, enough protein, low sugar, no junk food). I immediately implemented Holford's recommendations, and within 2 months had come off the pills and have never looked back (it's now 2 years). There were no other changes in my life at the time which could have contributed to this effect, so I am confident that it was down to nutrition. I'm not suggesting that everyone will be as fortunate as I was, but I do believe strongly that looking at one's diet is a logical first step to tackling depression, and I highly recommend this book to anyone suffering from it.