Most nutrients he mentions will help most people with PN. But there is one to beware of. Alpha lipoic acid is actually a great antioxidant and has been shown to be helpful in short term studies for PN pain. The problem is that if you have heavy metal toxicity (mercury) you need to be very very careful. ALA can definitely cross the blood brain barrier, and it can also bind to mercury, i.e., it is a chelator. If there is a lot of mercury in your body, as from mercury amalgam fillings in your teeth that are constantly releasing mercury, ALA can take more of it into your brain, and will likely bring on worsening of symptoms. To prevent this, it needs to be dosed on the chemical half life (which is 3 to 4 hours), and started at low doses. It typically doesn't make you worse until several months of use, (and this is why short term studies don't pick it up)thus it is difficult to make the connection. It happened to me, and it took me a long time to figure things out. For more info read Amalgam Illness by chemist Andrew Cutler PhD, or join the free Yahoo health discussion group frequent-dose-chelation.