I thoroughly enjoyed seasons 1 and 2, but I'm sorry to say season 3 'lost the plot'~ literally!
The thin storylines for Gloria Acolitis, Coop and Zoe (all great actors) made their presence almost unnecessary. Even (the wonderful) Eve Best's character did little apart from wander around the emergency unit, give Jackie a few 'heart to heart' talks, and buy a house, of which we did not see the inside, nor was it used in the plot.
Of course Edie Falco is a joy to watch, but she needs to get in some new WRITERS if ths is going to go UP hill again. Looking at details of the (still on-air) season 4 they have tried to solve it by bringing in 'guest stars'.. VERY bad move, unless the scripts get better as well.
We watched 'The Big C' with Laura Linney alternately with editions of 'Nurse Jackie'; it's 100% better, great (quirky) cast, incredible scripts, interwoven, tight sad-funny storylines, no wonder she won awards for it.The Big C - Season 1 [DVD] [2011