I am running Windows Media Center on Windows 7 Home Premium (64bit).
The remote comes with everything needed (batteries included!) although the USB cable for the receiver is a bit too short and I'll need an extender for that. Work straight away, The book that comes with describes how to program the remote to perform operations that affect your TV, this should be ideal to have the remote adjust the volume on the TV instead on the PC.
Looks and build wise, its a really good choice when you look at other remotes that are out there at the moment.