I am merely a hobby photographer and I will not attempt to make any more detailed review of this lens' performance. I leave it to those more qualified. There are several professional reviews available on the internet and I find that they are in good agreement that the lens is very good, except possibly for a somewhat weak tripod support (I use it freehand or on a monopod so I have no problem with that). My main use of the lens is nature photography, preferably animals and birds. After using it some time on my d5000 I have noticed that the success rate for my photos (i.e. the photos I like to save and display) is noticeably higher compared with most other lenses I have. I have learned to appreciate the lens also for portraits of my family members, especially the kids (i.e. fast-moving..). The lens is tack sharp also on f4 (no need to say), but it also makes a very nice and even exposure over the whole object. There is a nice "light" in the whole photo. I don't know why, but with my other lenses there is a stronger difference between bright and dark areas. They look like if subject to harder jpg compression. I would think this should be up to the sensor and the camera settings. It is like if this lens suddenly make use of the "active d lighting" of the camera, or something like that. It also suppresses the background wonderfully, not only by a lovely bokeh, but also through its nice control of the exposure throughout the image (e.g. an even dark or an even bright background fills up behind a perfectly exposed object). I admit my ignorance, but it is like magic how the lens "helps" me to take better photos!
My other telelens is a Nikon 55-200vr that I like very much. However, I found myself too often cropping the photos to a level where I pushed the capacity of the lens too far. Thus, I wanted something with more range. I was not interested in another zoom. I prefer to use my feet or to simply let the lens decide the frame (Is the duck too close.. then, well, I take a photo of its head instead). I also wanted a fast lens for low-light shots. Indeed, I have been out when the sun has dived well below the horizon and still the 300f4 gives me fast shutter speeds without that I have to push the ISO higher than 1000.
To me, the lens is less easy to use for birds in flight: It is not that it is any problem using it hand held during daytime, or any problem with the autofocus, it is fast enough when using the focus lock (>3m), but simply the narrow field of view that comes with the high magnification makes it difficult to locate the bird fast enough. For this my 55-200 is easier. However, with some training I may improve.
I am glad the 300f4 does not replace my 55-200vr, but instead complements it. The 55-200vr is much more portable and is good enough for many purposes. The 300f4 is bulkier, but takes better photos especially when one can be more stationary observing the wild life.
To make the 300f4 more portable I have connected it to a harness: I put a strap tightly around the lens just behind the focus ring where I obtain good balance with the camera attached. On the strap there is a ring. To this ring I connect the carabiners of a harness originally bought for a pair of binoculars (Bushnell). In this way the camera and attached lens hang comfortably across my lower chest. No strain to the back whatsoever. When an object appears the camera is ready in a flash. The elastic straps of the harness, when stretched out while the camera is held in front of the eyes, help to reduce vibrations (i.e. similar to the effect that can be achieved with a hunting rifle when applying the carrying sling in a certain way around the arm before the shot).
I am very satisfied with this lens. It was exactly what I had been looking for. It is a bit heavy, but I feel I solved it with the harness (so no risk it ends up unused at home). And the photos it generates are like.. magic. With this lens I will develop as a photographer and have great fun along the way.