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Natural Products: Discourse, Diversity and Design [Hardcover]

Anne Osbourn , Rebecca Goss , Guy T. Carter

Price: 133.00 & FREE Delivery in the UK. Details
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Book Description

29 April 2014 1118298063 978-1118298060 1
Natural Products: Discourse, Diversity and Design  provides an informative and accessible overview of discoveries in the area of natural products in the genomic era, bringing together advances across the kingdoms.  As genomics data makes it increasingly clear that the genomes of microbes and plants contain far more genes for natural product synthesis than had been predicted from the numbers of previously identified metabolites, the potential of these organisms to synthesize diverse natural products is likely to be far greater than previously envisaged.   Natural Products  addresses not only the philosophical questions of the natural role of these metabolites, but also the evolution of single and multiple pathways, and how these pathways and products may be harnessed to aid discovery of new bioactives and modes of action.   Edited by recognized leaders in the fields of plant and microbial biology, bioorganic chemistry and natural products chemistry, and with contributions from researchers at top labs around the world,  Natural Products  is unprecedented in its combination of disciplines and the breadth of its coverage.  Natural Produces: Discourse, Diversity and Design   will appeal to advanced students and experienced researchers, from academia to industry, in diverse areas including ecology, industrial biotechnology, drug discovery, medicinal chemistry, agronomy, crop improvement, and natural product chemistry.

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From the Back Cover

Natural Products: Discourse, Diversity, and Design explores the natural products, or the secondary metabolites, produced by microbes, fungi, and plants. Natural products can be used in the development of a wide array of products such as drugs, herbicides, antioxidants, preservatives, pigments and dyes for materials, food, flavors, and fragrances. As science advances, it has become exceedingly clear that the potential of biological organisms to synthesize diverse natural products is likely to be far greater than ever previously imagined. An accessible and informative overview of these natural products in the genomic era, Natural Products: Discourse, Diversity, and Design delves into the discovery, examination, and application of natural products across different kingdoms. Chapters explore their genetics and synthetic biology, methods for screening for bioactivity and their practical applications. Its wide scope guarantees its appeal to plant scientists, fungal biologists, and microbiologists, as well as those who work with industrial biotechnology, drug discovery, medicinal chemistry, agronomy, crop improvement, and natural product chemistry. The volume is comprehensive in its treatment of biologically based products in the natural world. Natural Products: Discourse, Diversity, and Design will be a vital resource for anyone working in this rapidly developing field. Covers a range of important natural products from microbes, plants, fungi, and marine organisms. • Explores the role of various metabolites as well as the evolution of their unique biochemical pathways. • Chapters cover topics including biosynthesis and heterologous expression, avoiding autotoxicity, and chemical diversification. • Includes case studies on the development of commercial products from natural products from industry experts. • Wide–ranging and in–depth coverage of an expanding field.

About the Author

The editors Anne Osbourn is Professor at the University of East Anglia, UK, and Director of the Norwich Research Park Industrial Biotechnology and Bioenergy Alliance, and is based at the John Innes Centre. Rebecca J. Goss is Reader in Organic/Biomolecular Chemistry at the School of Chemistry and also at the Biomedical Sciences Research Complex at the University of St Andrews, UK. Guy T. Carter has over 30 years of experience working in Pharmaceutical R&D, primarily in the discovery and development of microbial products. He is currently CEO of Carter–Bernan Consulting and Chief Scientific Officer at Biosortia Pharmaceuticals, USA.

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