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Molecular Toxicology Protocols (Methods in Molecular Biology) [Hardcover]

Phouthone Keohavong , Stephen G. Grant
5.0 out of 5 stars  See all reviews (1 customer review)
RRP: 117.00
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Book Description

22 Oct 2004 Methods in Molecular Biology (Book 291)
A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.

Product details

  • Hardcover: 460 pages
  • Publisher: Humana Press; 2005 edition (22 Oct 2004)
  • Language: English
  • ISBN-10: 1588290840
  • ISBN-13: 978-1588290847
  • Product Dimensions: 23.6 x 16.2 x 3.2 cm
  • Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Bestsellers Rank: 3,271,952 in Books (See Top 100 in Books)
  • See Complete Table of Contents

Product Description

Review

"This book should be of interest to both specialist researchers as well as members of the wider scientific community..." - British Journal of Anesthesiology

From the Back Cover

New state-of-the-art molecular techniques promise to transform the field of genetic toxicology by making it possible to directly detect genotoxic exposures and their consequences in humans, to identify the agent(s) involved, and to clinically manage the exposed population. In Molecular Toxicology Protocols, researchers from prominent universities and cancer centers around the world describe in detail their best techniques for analyzing genotoxic exposure and the resulting biological effects, including intermediate biomarkers such as DNA and chromosomal damage, mutations in reporter and oncogenes, and the earliest possible detection of cancer. The authors emphasize analytical methods specifically developed for use in human populations and in cancer patients, or in other in vivo systems such as transgenic mice. Among the applications detailed are the analysis of interactions of chemical and physical agents with cellular macromolecules, especially DNA, the assessment of medically relevant toxicity, and the individualized characterization of genetic damage and repair. There are also methods to assess and characterize the modulation of this damage and repair through individual differences in specific and genome-wide gene expression, including metabolic profiling and apoptotic capacity. These methods mark a shift in emphasis from studies of the agents themselves to the exposed population, and from studies of small populations with significant known exposures to a single agent, to studies of common diseases, such as breast cancer, caused by normal levels of generalized genotoxic exposure. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and highly practical, Molecular Toxicology Protocols offers a gold-standard collection of cutting-edge techniques designed to investigate a broad range of exposures-endogenous, accidental, medical, environmental, and occupational-and their role in human carcinogenesis and other diseases of aging.

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First Sentence
A common mechanism by which carcinogens initiate the process of malignant transformation is through damaging the DNA in the target organ in such a way that errors in replication can he induced. Read the first page
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5.0 out of 5 stars This book is indispensable for toxicologist 14 Jun 2012
Format:Hardcover|Verified Purchase
This book is indispensable for toxicologist. Whole topics have been explained as a clear. Protocols are understandable. I think this book will be useful for toxicologist, pharmacologist, genetician, molecular biologist and biochemists.
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