Cells in our body undergo tightly regulated replication to enable growth to occur in a precise, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail. The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal processes that become altered in cancer cells, and explains how the failure of these processes can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. Written with the student learner in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject - and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control. Online Resource Centre The Online Resource Centre to accompany The Molecular Biology of Cancer features: For students: * Hyperlinks to primary literature articles featured in the text * News feeds relevant to cancer biology, drawn from a variety of publications For registered adopters of the book: * Figures from the book, available to download * A test bank of questions, with feedback linked to the book, for use in formative or summative assessment
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Dr. Pecorino has done a fantastic job... The book's engaging writing-style and well thought out structure welcomes anyone with an interest in studying cancer in thorough, interesting detail. Reading this text was a pleasure, benefited me greatly educationally and made me feel like being a real part of the teaching - as though things were being explained to me in a one-on-one tutorial, an experience that most other medical textbooks don't provide! Amazon.co.uk reviewer Reviews of previous edition: Pecorino gets the balance right between cell and molecular biology, focusing on mechanism rather than disease. Importantly the students like the text and can afford to buy the book. Therefore it is a real support to our learning program and actually used by the students. Dr Bernard Mahon, Biology Department/Institute of Immunology, National University of Ireland Review from first edition The author's infectious enthusiasm as a teacher comes across on every page of this beautifully illustrated book. To guide her readers through this increasingly complex field, she introduces some novel features, including "Special interest" boxes, sections labelled, "Pause to think," well-designed chapter highlights and aids to "Memory refreshment." Given the speed of development of this field, the book is remarkably up to date. Sir David Weatherall, Emeritus Regius Professor of Medicine, Oxford University in THES Textbook Guide - February 2006
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Format:Paperback|Amazon Verified Purchase
i recommend this book to most of the students who needs to learn the cancer subject. it has a very clear way of teaching in simple but in scientific ways with the illisturations well drawn.
By B. Flaks
Format:Paperback|Amazon Verified Purchase
I found this rather disappointing. Having read a gushing review in "The Biologist", I had hoped for an up-to-date textbook on the subject. Instead I thought it rather superficial in its coverage. Just for example, its treatment of chemical carcinogenesis was very skimpy and ill-informed: the author is clearly not well acquainted with the subject (thinks the main carcinogen in tobacco smoke is benzo[a]pyrene and is unaware of tobacco-specific N-nitrosamines). The treatment of epigenetic carcinogenic mechanisms is vestigial and poor. Most of the molecular biological coverage adds little to the level of knowledge derived from 1950s research on the Morris minimal deviation hepatomas. The idea that this book offers any useful guide to cancer therapeutics in general is naive and wishful. Overall, the coverage is confused and confusing - I do not even like its "Dick and Jane" style, but that may be a personal preference.
It can be recommended to undergraduates studying Hair and Beauty, Cake Decorating or even Media Studies.
)I write as a former experimental cancer researcher of 35 years experience.)
It can be recommended to undergraduates studying Hair and Beauty, Cake Decorating or even Media Studies.
)I write as a former experimental cancer researcher of 35 years experience.)
1 of 2 people found the following review helpful
By rach
Format:Paperback|Amazon Verified Purchase
Good overview
Very readable
Fantastic layout, with wee boxes for asides and other bits of information
Makes you think and question rather than just pile heaps and heaps on information on you, which is exactly what I need for my course.
Ties in research methods and studies to explain how we know the things we know very nicely.
Could be more in depth in places, but then for that you could do your own research - this good is a good foundation point.
Very readable
Fantastic layout, with wee boxes for asides and other bits of information
Makes you think and question rather than just pile heaps and heaps on information on you, which is exactly what I need for my course.
Ties in research methods and studies to explain how we know the things we know very nicely.
Could be more in depth in places, but then for that you could do your own research - this good is a good foundation point.
1 of 2 people found the following review helpful
By Olga
Format:Paperback
Dr. Pecorino has done a fantastic job on her latest text, The Molecular Biology of Cancer, making it a very accessible and essential reading for university students (medics, scientists), and it's engaging writing-style and well thought out structure welcomes anyone with an interest in studying cancer in thorough, interesting detail.
There is a very natural layout to this text,the therapeutics are discussed in direct relationship to the mechanisms, with evaluations of what is currently possible as well as theoretical and evidence based suggestions for future therapies.
There are also some great personal touches from Dr. Pecorino, prompting one to "pause and think" at all the right moments, also including notes on "leaders in the field" and critical analyses of her own writing with the "how do we know that?" boxes.
Reading this text was a pleasure, benefited me greatly educationally and made me feel like being a real part of the teaching- as though things were being explained to me in a one-on-one tutorial, an experience that most other medical textbooks don't provide!
There is a very natural layout to this text,the therapeutics are discussed in direct relationship to the mechanisms, with evaluations of what is currently possible as well as theoretical and evidence based suggestions for future therapies.
There are also some great personal touches from Dr. Pecorino, prompting one to "pause and think" at all the right moments, also including notes on "leaders in the field" and critical analyses of her own writing with the "how do we know that?" boxes.
Reading this text was a pleasure, benefited me greatly educationally and made me feel like being a real part of the teaching- as though things were being explained to me in a one-on-one tutorial, an experience that most other medical textbooks don't provide!
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