This iteration of Publisher finally get's Microsoft's 'ribbon' (the replacement for the toolbar that first appeared in the rest of the Office suite (barring Outlook and Publisher itself) in 2007. That's something you'll either love or hate, but with 2010's version, the ribbons are all customisable, so you can make it suit the way you work.
There's a new 'Page Navigation' pane, which is helpful in getting an overview of the document (and rearranging pages if you want), and Publisher's photo-editing is - at last - the same as Word's (since 2007 small documents actually could be made to look better in Word!).
The greatest reason to choose Publisher as well as Word is when you're making documents to send to a commercial printer, when you can choose the "Save for Commercial Printer" command - outputting pdfs at a higher resolution than the Office/Word 'print to pdf' command. It's also better with bleeds (commercial printers all want a 3mm or 5mm 'bleed' around your document, and you'll need to see how it looks with the bleed.
Overall, it's a good, mid-range dtp program that has been - finally - updated properly. I found it a worthwhile upgrade from Publisher 2007. In terms of market 'pitch', I now much prefer Publisher to Serif (the look and feel is more modern, I find the program quicker in use, and it has a quick learning curve). For high-end use I'd still look to Adobe, but it should suit the small-medium size business perfectly. Amazon's price is very good too (undercutting Microsoft's download price at time of writing)