The other reviewers are right - this definitely is not a Tales of the City book. In terms of structure it is much, much closer to Maupin's later works "Maybe The Moon" and "The Night Listener".
I say this because unlike the other Tales books there is a single narrative, instead of a collection of sub-stories going on all at once. Personally, I enjoyed this book, but then I also enjoyed the two books mentioned above. Yes, I missed the excitement of following several intertwining stories that I so enjoyed in the earlier Tales books, but it does a pretty good job of holding its own.
There are some downsides to it - about three quarters of the way through you get a lot of rushed, un-necessary run-downs on what the old characters are up to now, which just seems shallow and detrimental to the novel as a whole, as well-loved characters from earlier titles are just brought up without adding to the story in the slightest. Maupin also repeated the unthinkable and killed off a much-loved character "off-screen", just like he did between Further Tales and Babycakes. I won't say who or how as that would take away from reading it, but it bothers me that he can be so blasé in killing off characters we all liked without even chronicling it properly in one of the stories.
Other than these shortcomings, it's still a good read and Maupin still has a great way with words. The story has plenty of Anna Madrigal in it which is never a bad thing, and Michael's biological family are portrayed well and have a good storyline. There are some likeable new characters such as Ben and Jake who the reader could easily warm to just as much as we did with the old characters if Maupin decides to continue the series in the future.
In summary, no it's not a Tales book, and no it's not Maupin's finest hour. But it is thoroughly readable and a welcome return from some of the characters so well-loved the first time around. I'd give it three-and-a-half stars if that were possible, but as it's not I'll give it four.