The author has a ton of technical information, yet seems to draw some weak conclusions; it's like he can't see the forest from the trees. The best example of this, and the worst part of the book imo, is when he shows a graph of what happens when you don't eat more than three times a day... just as things start to look good he adds another meal to mess things up again. The fact that he thinks eating "only" three times a day is a form of meal control that will magically solve everything reveals just how out of he is with the rest of the world non-nutritionist world. This is because he was taught that eating 6 meals/day was the optimal way to eat and he somehow thinks everyone has the dedication to eat this way... news flash: most people already eat 3x/day or less, this isn't going to help. We've fat reserves and an amino acid pool that can last us 2-3 days before eating our muscles, why not tell people to eat 1x/day in a large meal or a small eating window of a few hours like the promoters of intermitten fasting do? (or to eat 2 days' worth of protein, calories every other day) - this along with eating as few carbs as possible may even extend your lifespan if emerging studies are to be believed.
Another way he plays it too safe is to arbitrarily dismisses low carb/ketogenic diets because his inadequate government food pyramid-approved nutrionitist training said so. Wouldn't want to rock the boat and upset all your misguided nutritionist friends, now would we?
He also identifies the leptin-stress-insulin connection yet completely ignores insulin and acts as if it's all about the leptin; here's a hint: if someone has low-grade hyperinsulinaemia, from genetics and eating an evolutionnary inappropriate amount of carbs, just enough to keep the fat in fat cells from circulating in the blood, guess what happens when their enlarged fat cells secrete more leptin to tell your brain they need to lose fat? Nothing. The brain can tell your body to burn as much as it wants, and in the presence of elevated insulin fat cells can make all the leptin they want but nothing will happen except gradual leptin desensitization/resistance. To add insult to injury, your body will secrete large amounts of adrenaline to temporarily raise blood sugar levels when your sugar/carb metabolism starts to break down and you begin to experience reactive hypoglycaemia (low blood sugar) as part of the viscious cycle of hyperglycaemia (too much blood sugar), insulin resistance and hyperinsulinaemia (elevated insulin levels) that makes us fat and, based on our genes, can ultimately give us Type II Diabetes.
Unless an overweight person eat meals of raw fructose 12x / day chances are they're insulin resistant not leptin resitant, especially when you consider that we modern humans eat way too many carbs, especially the hepatoxic fructose sugar that slows down your liver's ability to respond to dangerously elevated glucose. (The average hunter-gatherer only ate about 80 grams of digestible carbs/day) - this isn't even mentioning eating plant-based foods whose chemical defenses we've never adapted to properly (i.e. grains, soy/legumes), or our messed-up Omega-6:3 ratios...
If you want some good information don't buy this book, go look at blogs on paleolithic/evolution-based nutrition (which won't cost you anything), and go read Gary Taubes' DD
On the plus side, he does provide a lot of technical information... too bad he can't get beyond his basic nutritionist training, which is based on dangerously outdated government-mandated dietary guidelines