This is an excellent bag. I've used 3 different Lowepro bags (the other two being Toploader 65 AW and Fastpack 250) and I really like Lowepro bags for their quality and good padding which secures my camera and lenses. The only reason for replacing my Lowepro Fastpack 250 by Pro Runner 350AW was that I've got bigger lenses and more kit so Fastpack 250 wasn't big enough anymore. I thought about getting Pro Runner 450AW, but that one is way to big to be used as hand luggage on planes. Pro Runner 350AW is still big, but it violates the usual airlines requirements only by 1cm in one dimension (450AW by 5cm!) which I hope is OK. My bag fits a 5Dmk2 (without the battery grip, seems to me 5d with a battery grip would struggle to fit, but haven't tried), 70-200f4, 24-105f4, couple of filter cases, 430 flash with a difuser, 50f1.4, cleaning kit, charger with cables, table mini-tripod, RSS pano kit, card reader and there is still room for laptop cables and charger if necessary. Strongly recommended.