Before getting this bag, I'd advise you to try ANY bag in a shop first. I looked at quite a few online (written and video reviews) before settling on this bag. However, on receipt, I'm not as satisfied as I'd hoped.
The bag holds the items quite well, although the smaller body DLSR cameras won't find in as flush as some of the bigger body models.
The top half of the bag a ok in size, but by time you add a few accessories (filters, cables etc), it doesn't leave a huge amount left for clothes.
Be careful if you are choosing this, in that (as it does probably say), it has space for a laptop. If you don't need to ever carry a laptop (like me), then this adds some unnessecary bulk to the bag
It's guite comfortable to wear and only started achaing after about 6 hours of walking.
The main reason why I'd suggest trying this out in a shop first, is the camera access panel. In theory, it works, but in practice, its not as fluid as some of the video reviews may suggest. When it comes to changing a lens, you need to take it off your back completely.
In hindsight, I would have probably have gone for the flipside model instead to avoid putting the bag up and down on the floor. Or if you don't mind doing that, possibly the Tamrac Adventure 7 Tamrac 5546 Adventure 6 Backpack - Grey
may be worth looking at.
Hope this helps