I discovered the benefits of DMSO while stationed in Hawaii 30 years ago. Although I had no use for this product at that time, thirty years makes a difference. DMSO was discovered over 140 years ago and is an extract from a tree. It has been in use for over a century with no know side effects when used with common sense. Outside of the US, DMSO is routinely prescribed by doctors for treatment. Check up (Google) on DMSO to find out what and how to use - just rub it on clean skin (DMSO is absorbed directly through the skin) :) Big pharma doesn't like this product as it negates their expensive drugs. You decide.